Hormones and Understanding Set Point Shifts Through the Decades

Dr. Debra Lewis
Apr 14, 2025By Dr. Debra Lewis


We know our bodies are amazing, constantly changing and adapting throughout our lives. As we journey through our 40s, 50s, and beyond, one of the most significant shifts we experience is in our hormones. These powerful chemical messengers influence everything from our mood and sleep to our energy levels and, yes, our weight. Understanding how these hormonal changes can interact with our body's natural "set point" can bring a new level of self-awareness and compassion to our wellness journey.

Remember that "set point" we talked about? That weight range your body naturally tries to maintain? Well, the hormonal shifts we experience, particularly during perimenopause and menopause, can gently nudge that set point.

The Estrogen Connection:

As estrogen levels naturally decline during perimenopause and menopause, several things can happen that might influence our weight:

Lower estrogen levels can encourage the body to store more fat around the abdomen, rather than the hips and thighs. This shift in fat distribution is a common experience and is linked to various health considerations.

While not solely attributed to estrogen, the hormonal changes, combined with natural aging and potential loss of muscle mass, can contribute to a gradual slowing of our metabolism. This means we might burn fewer calories at rest.

Some studies suggest that declining estrogen can impact insulin sensitivity, potentially making it easier to store fat.

Hormonal fluctuations can lead to hot flashes and night sweats, disrupting our sleep. Poor sleep can, in turn, affect our hunger hormones (ghrelin and leptin), potentially leading to increased appetite and cravings for less nutritious foods.

It's Not Just About Estrogen:

While estrogen plays a significant role, other hormonal shifts can also be at play. Changes in progesterone and even slight shifts in testosterone levels can also influence body composition and metabolism.

What This Means for Your Happy Weight:

Understanding these hormonal influences on our set point doesn't mean we're powerless. Instead, it empowers us to approach our health with greater awareness and self-compassion:

If you notice your body settling into a slightly different weight range during this time, remember that hormonal shifts are a natural part of this life stage. Avoid harsh self-criticism and focus on overall well-being.

Instead of solely focusing on weight, prioritize habits that support hormonal balance and overall health. This includes a whole foods-based diet rich in fruits, vegetables, and healthy fats, regular joyful movement (including strength training to maintain muscle mass), stress management techniques, and prioritizing quality sleep.

Pay attention to your hunger and fullness cues. Embrace intuitive eating principles and nourish your body with what it truly needs.

If you're struggling with significant weight changes or other menopause-related symptoms, don't hesitate to talk to your healthcare provider. They can offer personalized advice and support.

Our bodies are wise and resilient. Understanding how our hormones influence our natural weight range allows us to navigate this chapter with grace, focusing on sustainable health and celebrating the incredible journey we're on.